Angiogenic Potential of Prostate Carcinoma Cells Overexpressing bcl-2
نویسندگان
چکیده
منابع مشابه
Angiogenic potential of prostate carcinoma cells overexpressing bcl-2.
BACKGROUND Tumors commonly outgrow their blood supply, thereby creating hypoxic conditions, which induce apoptosis and increase expression of angiogenic growth factors. The bcl-2 oncogene inhibits apoptosis induced by a variety of stimuli, including hypoxia. On the basis of bcl-2's role in regulating apoptosis in response to hypoxia, we hypothesized that this oncogene might affect other respons...
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The mechanism of action of the oncogene bcl-2 , a key regulator of the apoptotic process, is still debated. We have employed organelle-targeted chimeras of the Ca 2 1 -sensitive photoprotein, aequorin, to investigate in detail the effect of Bcl-2 overexpression on intracellular Ca 2 1 homeostasis. In the ER and the Golgi apparatus, Bcl-2 overexpression increases the Ca 2 1 leak (while leaving C...
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We have investigated the expression of bcl-2 protein in a panel of small cell lung carcinoma (SCLC) cells lines. Five of six cell lines examined expressed relatively high levels of bcl-2 protein and transcripts. The bcl-2 expression in SCLC cells, however, was not always associated with myc expression. Since dysregulation of bcl-2 may be involved in the course of tumorigenesis and/or in the acq...
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The study tested the hypothesis that transplantation of embryonic stem (ES) cells into rat cortex after a severe focal ischemia would promote structural repair and functional recovery. Overexpression of the human anti-apoptotic gene bcl-2 in ES cells was tested for increasing survival and differentiation of transplanted cells and promoting functional benefits. Mouse ES cells, pretreated with re...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2001
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/93.3.208